第五十四期“青年学者论坛”——王秀杰、陈玲玲学术报告会

应我校青年学者论坛邀请,中国科学院遗传与发育生物学研究所王秀杰研究员、中国科学院生物化学与细胞生物学研究所陈玲玲研究员来访我校,访问期间将举办学术报告进行交流,欢迎相关师生参加。

(一)报告题目:RNA m6A 修饰的产生机制与功能研究

报告人:王秀杰 研究员

报告时间:523日(周)下午14:00

(二)报告题目:Linking RNA Processing and Function

报告人:陈玲玲 研究员

报告时间:523日(周)下午15:30

 

主持人:黄志伟 教授

报告地点:活动中心326

主办单位:人事处

承办单位:生命科学中心/生命科学与技术学院

报告人简介:

(一)王秀杰,中科院遗传发育所研究员、分子系统生物学研究中心主任。1998年获得南开大学生物专业学士学位,2000年获得香港科技大学生物化学专业硕士学位,2004年获得美国洛克菲勒大学生物信息学专业博士学位,同年加入中科院遗传发育所任研究员,入选中科院百人计划。主要从事非编码RNA的系统发现和功能相关的生物信息学与实验生物学研究,发表SCI论文102篇,他引9000余次,H-index为50,多项工作得到ScienceNowNature Review Genetics等科技媒体的推荐。2007年获得国家杰出青年科学基金。曾获得中央国家机关五四奖章标兵中国青年五四奖章全国五一巾帼标兵全国三八红旗手等荣誉称号。2014年和2016年分别作为第二完成人和第四完成人获得国家自然科学奖二等奖。入选中组部万人计划领军人才,获得首届中源协和生命医学创新突破奖和第八界中国侨界贡献奖一等奖。中国共产党第十九次全国代表大会代表。

(二)陈玲玲,2009年毕业于美国康涅狄格大学获得生物医学博士和管理学硕士学位,2011年初任中国科学院分子细胞科学卓越创新中心研究员。2017年入选霍徳华休斯医学研究所(HHMI) 国际研究员,国家自然科学基金委杰出青年。陈玲玲长期从事RNA代谢和功能研究她创建并利用RNA研究的新技术体系,发现包括环形RNA和小核仁RNA结尾的长非编码RNA等新型RNA分子家族及其在哺乳动物细胞中普遍存在、解析它们全新的生成加工途径、揭示新型RNA在细胞核亚结构域功能、天然免疫调控中的重要机制并与小胖威利综合征、自身免疫失调等疾病密切关联。这些工作以全新视角揭示哺乳动物转录组复杂性及长非编码RNA的多样性和重要功能。以 (共同) 通讯作者在Cell (5 篇)、Science (2篇)、Nat Rev Mol Cell Biol (3篇)、Mol Cell (9篇)、Nat Cell Biol (2篇)、Nat Methods等期刊发表 50 余篇论文。受邀担任CellScienceMol Cell等多个期刊的编委,担任美国冷泉港实验室会议、冷泉港亚洲会议、国际RNA学会年会等大会主席。曾获CBIS青年研究员奖、中国青年女科学家奖、谈家桢生命科学创新奖、中科院青年科学家奖、中国青年科技奖特别奖、科学探索奖、国际RNA学会Mid-Career Research Award等学术奖励。陈玲玲实验室网页:http://www.chenlab-ncrna.com/.

报告摘要:

1.As the most abundant modification on mRNAs, N6-methyladenosine (m6A) has been found to play essential roles in regulating development, metabolism, immune response, as well as many other physiological and pathological processes. In combination of bioinformatics and experimental biology approaches, we and collaborators have shown that the formation of m6A is mediated by microRNAs. We also found that the learning process activates m6A formation thus enhances the efficacy of long-term memory formation. To decipher the underlying mechanism, we have found an activator for METTL3, the major methyltransferase for m6A formation. We also identified a chemical compound that can activate METTL3 through the aforementioned upstream regulator. Application of the chemical compound at cellular and animal level can both enhance METTL3 activity and m6A abundance, and is capable to improve the learning efficacy in mice. In addition, we also revealed a role of m6A in regulating fat metabolism and metabolic cardiomyopathy.

2.Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes.  Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs.  By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several distinct RNA species with unexpected formats.  These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by different mechanisms, including capping by small nucleolar RNA (snoRNA)protein (snoRNP) complexes at their ends or forming circular structures.  We have shown that some such RNAs are involved in gene regulation and implicated in human diseases such as Prader-Willi Syndrome and the autoimmune disease systemic lupus erythematosus.  In this talk, I will discuss our most recent findings on their biogenesis, mechanisms of action and potential application of these unconventionally processed circular and long ncRNAs in human health and disease.

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